反应详情

To a solution of N-(4-(cyclohexylsulfinylmethyl)-phenyl)-7-(4-methylphenyl)-2,3-dihydro-1-benzoxepine-4-carboxamide (0.13g) in chloroform (45ml) was added 70% m-chloroperbenzoic acid (mCPBA) (0.097g) under ice-cooling, and the mixture was stirred at room temperature for 30 minutes. To the mixture was added sodium thiosulfate solution, and the mixture was washed with sodium hydrogen carbonate solution and water, and dried with anhydrous magnesium sulfate. Under reduced pressure, the solvent was evaporated to give crude crystals, which were recrystallized from ethanol-hexane to give N-(4-(cyclohexylsulfonylmethyl)-phenyl)-7-(4-methylphenyl)-2,3-dihydro-1-benzoxepine-4-carboxamide (Compound 107) (0.11g) as

1. temperaturecooling
2. washthe mixture was washed with sodium hydrogen carbonate solution and water
3. dry with materialdried with anhydrous magnesium sulfate
4. customUnder reduced pressure, the solvent was evaporated
5. customto give crude crystals, which
6. customwere recrystallized from ethanol-hexane