反应详情

In two portions of equal size, a total of 2.00 g (10.0 mmol) of methyl 2-fluoro-4-nitrobenzoate and 2.51 g (50.2 mmol) of hydrazine monohydrate in 36 ml of ethanol were heated in a microwave reactor at 120° C. for 2 h. The combined reaction solutions were diluted with ethyl acetate and washed with water. The aqueous phase was extracted three times with ethyl acetate. The combined organic phases were dried over magnesium sulphate and concentrated under reduced pressure. Yield: 1.66 g (purity 95%, 88% of theory)

1. customThe combined reaction solutions
2. washwashed with water
3. extractionThe aqueous phase was extracted three times with ethyl acetate
4. dry with materialThe combined organic phases were dried over magnesium sulphate
5. concentrationconcentrated under reduced pressure