反应详情

5-Amino-2-bromo-4-fluorophenol (10.30 g), ethyl iodide (9.36 g) and potassium carbonate (7.59 g) were suspended in acetonitrile (100 ml), and the mixture was heated under refluxing for about 6 hours. After the reaction, the precipitates were filtered, the solvent was distilled off, extracted with ethyl acetate, and dried over anhydrous magnesium sulfate. Then, ethyl acetate was distilled off, and the resulting oily substance was purified by chromatography on silica gel (ethyl acetate:n-hexane=1:3 v/v) to obtain the objective 4-bromo-5-ethoxy-2-fluoroaniline (7.93 g).

1. temperaturethe mixture was heated
2. temperatureunder refluxing for about 6 hours
3. customAfter the reaction
4. filtrationthe precipitates were filtered
5. distillationthe solvent was distilled off
6. extractionextracted with ethyl acetate
7. dry with materialdried over anhydrous magnesium sulfate
8. distillationThen, ethyl acetate was distilled off
9. customthe resulting oily substance was purified by chromatography on silica gel (ethyl acetate:n-hexane=1:3 v/v)