反应详情

10 mg (0.036 mmol) of 5-amino-3-methyl-(3-nonyl)-1H-pyrazole-4-carboxamide and 57 mg (0.274 mmol) of methyl 3,4-dimethoxyphenylacetate are refluxed for 6 hours in 0.5 ml of a 0.5M ethanolic sodium ethoxide solution. After dichloromethane and saturated aqueous sodium hydrogen carbonate solution have been added, the phases are separated. Purification by chromatography gives 7.3 mg (48%) of a solid, Rf=0.57 (dichloromethane/methanol=15:1).

1. customthe phases are separated
2. customPurification by chromatography