反应详情

18 mg (0.065 mmol) of 5-amino-3-ethyl-1-(3-nonyl)-1H-pyrazole-4-carboxamide and 69 mg (0.323 mmol) of methyl 3-chloro-4-methoxyphenylacetate are refluxed for 6 hours in 0.5 ml of a 0.5M ethanolic sodium ethoxide solution. After dichloromethane and saturated aqueous sodium hydrogen carbonate solution have been added, the phases are separated. Purification by chromatography gives 8 mg (28%) of a solid, Rf=0.75 (dichloromethane/methanol=15:1).

1. customthe phases are separated
2. customPurification by chromatography