Hydrogen chloride-ethyl acetate → HCID 88146823, compound

HRID 566420Notes

Reaction equation

HRID 566420 reaction equation
[ClH:1].C(OCC)(=O)C.[CH3:8][N:9]([CH3:45])[CH2:10][CH2:11][CH2:12][NH:13][C:14]([O:16][CH2:17][CH:18]1[CH:23]([N:24]([CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH3:44])[CH:25]=[O:26])[CH2:22][CH:21]=[CH:20][CH2:19]1)=[O:15]>C(OCC)(=O)C.C(O)C>[ClH:1].[CH3:45][N:9]([CH3:8])[CH2:10][CH2:11][CH2:12][NH:13][C:14]([O:16][CH2:17][CH:18]1[CH:23]([N:24]([CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH3:44])[CH:25]=[O:26])[CH2:22][CH:21]=[CH:20][CH2:19]1)=[O:15]

Participants

5

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 88145594HCID 88145594, compound

Product 1

HCID 88146823HCID 88146823, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

4N Hydrochloric acid/ethyl acetate solution (0.19 ml) was added to a solution of [6-[[N-[3-(dimethylamino)propyl]carbamoyloxy]methyl]-3-cyclohexenyl]-N-octadecylformamide (0.20 g) in ethyl acetate (4 ml) while being cooled with ice and then stirred for 10 minutes. The deposited crystals were dissolved in ethanol and concentrated. The residue was crystallized with ethyl acetate, thereby yielding the entitled compound (0.21 g) as white crystals.

Workup

  1. temperaturewhile being cooled with ice
  2. concentrationconcentrated
  3. customThe residue was crystallized with ethyl acetate

Sources & evidence

ORD record
ord-bd8847ebb6e04ecdb195d887da3bc8fb
Source dataset
uspto-grants-2001_01
Patent number
US06174885B1

Reaction notes

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