HCID 9916894, compound → HCID 21266130, compound

HRID 566423Notes

Reaction equation

HRID 566423 reaction equation
[ClH:1].C(OCC)(=O)C.[CH2:8]([N:15]1[CH2:20][CH2:19][N:18]([C:21]([O:23][CH2:24][CH:25]2[CH:30]([C:31]([NH:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][CH2:49][CH2:50][CH3:51])=[O:32])[CH2:29][CH:28]=[CH:27][CH2:26]2)=[O:22])[CH2:17][CH2:16]1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>C(OCC)(=O)C>[ClH:1].[CH2:8]([N:15]1[CH2:16][CH2:17][N:18]([C:21]([O:23][CH2:24][CH:25]2[CH:30]([C:31]([NH:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][CH2:49][CH2:50][CH3:51])=[O:32])[CH2:29][CH:28]=[CH:27][CH2:26]2)=[O:22])[CH2:19][CH2:20]1)[C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

Participants

4

Reactant 2

HCID 9916894HCID 9916894, compoundHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 21266130HCID 21266130, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

4N Hydrochloric acid/ethyl acetate solution (1.28 ml) was added to a solution of {6-[(octadecylamino)carbonyl]-3-cyclohexenyl}methyl 4-benzyltetrahydro-1(2H)-pyrazine carboxylate (2.600 g) in ethyl acetate (26 ml). After being stirred for half an hour at room temperature, the reaction mixture was concentrated. The residue was recrystallized with ethyl acetate-ethanol mixed solution, thereby yielding the entitled compound (2.412 g) as white solid.

Workup

  1. concentrationthe reaction mixture was concentrated
  2. customThe residue was recrystallized with ethyl acetate-ethanol mixed solution

Sources & evidence

ORD record
ord-1b90dfc5b80243788cf10735435511dd
Source dataset
uspto-grants-2001_01
Patent number
US06174885B1

Reaction notes

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