[6-[[(2-Piperidinoethyl)amino]carbonyl]-3-cyclohexenyl]methyl N-octadecylcarbamate → [6-[[(2-Piperidinoethyl)amino]carbonyl]-3-cyclohexenyl]methyl N-octadecylcarbamate hydrochloride

HRID 566428Notes

Reaction equation

HRID 566428 reaction equation
[ClH:1].C(OCC)(=O)C.[CH2:8]([NH:26][C:27](=[O:47])[O:28][CH2:29][CH:30]1[CH:35]([C:36]([NH:38][CH2:39][CH2:40][N:41]2[CH2:46][CH2:45][CH2:44][CH2:43][CH2:42]2)=[O:37])[CH2:34][CH:33]=[CH:32][CH2:31]1)[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]>C(OCC)(=O)C>[ClH:1].[CH2:8]([NH:26][C:27](=[O:47])[O:28][CH2:29][CH:30]1[CH:35]([C:36]([NH:38][CH2:39][CH2:40][N:41]2[CH2:42][CH2:43][CH2:44][CH2:45][CH2:46]2)=[O:37])[CH2:34][CH:33]=[CH:32][CH2:31]1)[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]

Participants

4

Reactant 2

HCID 21266136[6-[[(2-Piperidinoethyl)amino]carbonyl]-3-cyclohexenyl]methyl N-octadecylcarbamateHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 21266171[6-[[(2-Piperidinoethyl)amino]carbonyl]-3-cyclohexenyl]methyl N-octadecylcarbamate hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

4N Hydrochloric acid/ethyl acetate solution (1.30 ml) was added to a solution of [6-[[(2-piperidinoethyl)amino]carbonyl]-3-cyclohexenyl]methyl N-octadecylcarbamate (2.431 g) in ethyl acetate (50 ml). After being stirred for 30 minutes at room temperature, the reaction mixture was concentrated. The residue was recrystallized with methanol-isopropyl ether mixed solution, thereby yielding the entitled compound (2.407 g) as white solid.

Workup

  1. concentrationthe reaction mixture was concentrated
  2. customThe residue was recrystallized with methanol-isopropyl ether mixed solution

Sources & evidence

ORD record
ord-cb4c4b26a0ef44769355e54b783f5e9e
Source dataset
uspto-grants-2001_01
Patent number
US06174885B1

Reaction notes

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