Trifluoroacetic acid → 2-[4-(2-Bromo-5-chlorophenyl)-2-oxopyridin-1(2H)-yl]propanoic acid

HRID 56646Notes

Reaction equation

HRID 56646 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][N:12]([CH:15]([CH3:23])[C:16]([O:18]C(C)(C)C)=[O:17])[C:11](=[O:24])[CH:10]=1.C(O)(C(F)(F)F)=O>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][N:12]([CH:15]([CH3:23])[C:16]([OH:18])=[O:17])[C:11](=[O:24])[CH:10]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 117622670tert-Butyl 2-[4-(2-bromo-5-chlorophenyl)-2-oxopyridin-1(2H)-yl]propanoate

Product 1

HCID 1176226782-[4-(2-Bromo-5-chlorophenyl)-2-oxopyridin-1(2H)-yl]propanoic acid

Procedure

920 mg (2.2 mmol) of tert-butyl 2-[4-(2-bromo-5-chlorophenyl)-2-oxopyridin-1(2H)-yl]propanoate (racemate) were hydrolysed with TFA according to General Method 6A. Yield: 1110 mg (purity 93%, quant.)

Sources & evidence

ORD record
ord-4304d1d4dacb420f9389b0f928691396
Source dataset
uspto-grants-2016_09
Patent number
US09434690B2

Reaction notes

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