反应详情

To a solution of dibenzyl malonate (0.5 g) in DMF (4 mL), was added sequentially NaH (0.12 g, 80% in mineral oil), di(tert-butyl) [[4-(bromomethyl)phenyl](difluoro)methyl]phosphonate (1.60 g). The reaction mixture was stirred at room temperature for 1 h, then quenched with 20 mL of saturated aqueous NH4Cl solution and extracted with 50 mL EtOAc. The extract was dried over Na2SO4 and concentrated. The residue was purified by silica gel chromatography eluted with 1:1 hexane/EtOAc to give the title compound (0.3 g).

1. customquenched with 20 mL of saturated aqueous NH4Cl solution
2. extractionextracted with 50 mL EtOAc
3. dry with materialThe extract was dried over Na2SO4
4. concentrationconcentrated
5. customThe residue was purified by silica gel chromatography
6. washeluted with 1:1 hexane/EtOAc