HCID 21265690, compound → HCID 17903582, compound

HRID 566498Notes

Reaction equation

HRID 566498 reaction equation
[CH2:1]([NH:8][C:9](=[O:59])[C:10]([CH2:37][C:38]1[CH:43]=[CH:42][C:41]([C:44]([P:47]([O:54]C(C)(C)C)([O:49]C(C)(C)C)=[O:48])([F:46])[F:45])=[CH:40][CH:39]=1)([CH2:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]([P:25]([O:32]C(C)(C)C)([O:27]C(C)(C)C)=[O:26])([F:24])[F:23])=[CH:18][CH:17]=1)[C:11]([O:13][CH3:14])=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(Cl)Cl.C(O)(C(F)(F)F)=O>[CH2:1]([NH:8][C:9](=[O:59])[C:10]([CH2:37][C:38]1[CH:39]=[CH:40][C:41]([C:44]([F:46])([F:45])[P:47]([OH:54])([OH:49])=[O:48])=[CH:42][CH:43]=1)([CH2:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]([F:23])([F:24])[P:25]([OH:32])([OH:27])=[O:26])=[CH:18][CH:17]=1)[C:11]([O:13][CH3:14])=[O:12])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 21265690HCID 21265690, compound

Product 1

HCID 17903582HCID 17903582, compoundYield 116.7%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of methyl 3-(benzylamino)-2,2-di{4-[(di-tert-butoxyphosphoryl)(difluoro)methyl]benzyl}-3-oxopropanoate (15 mg) in 2 mL of CH2Cl2 and 1.5 mL of TFA was stirred for 2 h and then concentrated. The residue was dissolved in 3 mL of water and washed with 3×2 mL of ether and the aqueous solution was lyopholized to give 13 mg of the title compound as a white solid.

Workup

  1. concentrationconcentrated
  2. dissolutionThe residue was dissolved in 3 mL of water
  3. washwashed with 3×2 mL of ether

Sources & evidence

ORD record
ord-87a17a241073445fb8b61dd10c27f840
Source dataset
uspto-grants-2001_01
Patent number
US06174874B1

Reaction notes

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