反应详情

温度

60 °C

A solution of dimethyl 2-(4-bromobenzyl)malonate (4.2 g), 1-(bromomethyl)-4-(diethoxymethyl)benzene (4 g) in DMF (50 mL) was treated with NaH (0.8 g, 60% in mineral oil). The mixture was stirred for 2 h at 60° C., and then quenched with 100 mL of 50% saturated NH4Cl. The product was extracted with 200 mL of 2:1 hexane/EtOAc. The extract was dried over Na2SO4 and concentrated, and dried under vacuum to give the title compound which was used without further purification.

1. customquenched with 100 mL of 50% saturated NH4Cl
2. extractionThe product was extracted with 200 mL of 2:1 hexane/EtOAc
3. dry with materialThe extract was dried over Na2SO4
4. concentrationconcentrated
5. customdried under vacuum