Sodium Hydroxide → HCID 21265708, compound

HRID 566516Notes

Reaction equation

HRID 566516 reaction equation
C([O:5][P:6]([C:13]([F:48])([F:47])[C:14]1[CH:46]=[CH:45][C:17]([CH2:18][C:19]([C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=2)([C:31](=[O:38])[C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH2:20][C:21]2[CH:30]=[CH:29][C:24]([C:25]([O:27]C)=[O:26])=[CH:23][CH:22]=2)=[CH:16][CH:15]=1)([O:8]C(C)(C)C)=[O:7])(C)(C)C.[OH-].[Na+]>C1COCC1>[F:48][C:13]([F:47])([P:6]([OH:7])([OH:8])=[O:5])[C:14]1[CH:46]=[CH:45][C:17]([CH2:18][C:19]([C:39]2[CH:40]=[CH:41][CH:42]=[CH:43][CH:44]=2)([C:31](=[O:38])[C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH2:20][C:21]2[CH:22]=[CH:23][C:24]([C:25]([OH:27])=[O:26])=[CH:29][CH:30]=2)=[CH:16][CH:15]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 21265744HCID 21265744, compound

Product 1

HCID 21265708HCID 21265708, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To the compound of Step 1 (0.040 g, 0.059 mmol) was treated as described in Example 19 Step 6. To the crude mixture was added 2 mL of THF and 1 mL of 1N NaOH. After a period of 18 h at 60° C., the mixture was evaporated and purified by RP-HPLC.

Workup

  1. customthe mixture was evaporated
  2. custompurified by RP-HPLC

Sources & evidence

ORD record
ord-8a63c80cb33345e1ac6c64dff01d9bf7
Source dataset
uspto-grants-2001_01
Patent number
US06174874B1

Reaction notes

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