Sodium hydride → HCID 54207148, compound

HRID 566607Notes

Reaction equation

HRID 566607 reaction equation
[H-].[Na+].[NH2:3]/[C:4](/[C:11]([F:14])([F:13])[F:12])=[CH:5]\[C:6]([O:8]CC)=O.[CH2:15]([O:17][N:18]=[CH:19][C:20]1[CH:25]=[C:24]([N:26]=[C:27]=[O:28])[C:23]([Cl:29])=[CH:22][C:21]=1[Cl:30])[CH3:16]>>[CH2:15]([O:17][N:18]=[CH:19][C:20]1[CH:25]=[C:24]([N:26]2[C:6](=[O:8])[CH:5]=[C:4]([C:11]([F:12])([F:13])[F:14])[NH:3][C:27]2=[O:28])[C:23]([Cl:29])=[CH:22][C:21]=1[Cl:30])[CH3:16]

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 5702529Ethyl 3-amino-4,4,4-trifluorocrotonateHCID 57052211HCID 57052211, compound

Product 1

HCID 54207148HCID 54207148, compound

Procedure

9.2 g (0.31 mol) of sodium hydride, 51.3 g (0.28 mol) of ethyl 3-amino-4,4,4-trifluorocrotonate and 72.6 g (0.28 mol) of 2,4-dichloro-5-isocyanatobenzaldehyde (O-ethyl)oxime were reacted in the manner described for precursor 3.2. Yield: 72.0 g; m.p.: 205-209° C.

Sources & evidence

ORD record
ord-028caa2ab41d4ae1a00625cadb1f08ff
Source dataset
uspto-grants-2001_01
Patent number
US06175007B1

Reaction notes

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