Lithium Hydroxide → 2-(4-Bromo-2-oxopyridin-1(2H)-yl)-3-cyclopropylpropanoic acid

HRID 56666Notes

Reaction equation

HRID 56666 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][N:5]([CH:8]([CH2:14][CH:15]2[CH2:17][CH2:16]2)[C:9]([O:11]CC)=[O:10])[C:4](=[O:18])[CH:3]=1.[OH-].[Li+]>>[Br:1][C:2]1[CH:7]=[CH:6][N:5]([CH:8]([CH2:14][CH:15]2[CH2:17][CH2:16]2)[C:9]([OH:11])=[O:10])[C:4](=[O:18])[CH:3]=1

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 117622870Ethyl 2-(4-bromo-2-oxopyridin-1(2H)-yl)-3-cyclopropylpropanoate

Product 1

HCID 1176225472-(4-Bromo-2-oxopyridin-1(2H)-yl)-3-cyclopropylpropanoic acid

Procedure

350 mg (1.1 mmol) of ethyl 2-(4-bromo-2-oxopyridin-1(2H)-yl)-3-cyclopropylpropanoate (racemate) were hydrolysed with lithium hydroxide according to General Method 6B. Yield: 290 mg (purity 94%, 86% of theory)

Sources & evidence

ORD record
ord-0c9a144a9b9f4cbc8f14ce86af75f9a6
Source dataset
uspto-grants-2016_09
Patent number
US09434690B2

Reaction notes

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