m-Anisoyl chloride → HCID 21264403, compound

HRID 567093Notes

Reaction equation

HRID 567093 reaction equation
[F:1][C:2]([F:19])([F:18])[C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[C:14]3[CH:15]=[CH:16][S:17][C:13]=3[CH2:12][CH2:11][NH:10]2)=[CH:5][CH:4]=1.C(N(C(C)C)CC)(C)C.[C:29](Cl)(=[O:38])[C:30]1[CH:35]=[CH:34][CH:33]=[C:32]([O:36][CH3:37])[CH:31]=1>ClCCl>[F:19][C:2]([F:1])([F:18])[C:3]1[CH:4]=[CH:5][C:6]([CH:9]2[C:14]3[CH:15]=[CH:16][S:17][C:13]=3[CH2:12][CH2:11][N:10]2[C:29]([C:30]2[CH:35]=[CH:34][CH:33]=[C:32]([O:36][CH3:37])[CH:31]=2)=[O:38])=[CH:7][CH:8]=1

Participants

5

Reactant 3

HCID 74374m-Anisoyl chlorideHCID 81531DiisopropylethylamineHCID 2739390HCID 2739390, compound

Product 1

HCID 21264403HCID 21264403, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4-(4-Trifluoromethylphenyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine (100 mg, 0.35 mmol) was dissolved in dichloromethane (1 mL) and diisopropylethylamine (0.5 mL) was added. To this solution m-anisoyl chloride (50 μL, 0.35 mmol) was added. The mixture was shaken overnight and evaporated to afford the title compound.

Workup

  1. customevaporated

Sources & evidence

ORD record
ord-466aacee0a1b471c854e83464e03553d
Source dataset
uspto-grants-2001_01
Patent number
US06177443B1

Reaction notes

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