反应详情

A solution of 4-(4-Trifluoromethoxyphenyl)4,5,6,7-tetrahydro-thieno[3,2-c]pyridine in N,N-dimethylformamide (0.375 M, 0.4 ml, 0.15 mmol) was added to a solution of 4-methoxybenzoic acid in N,N-dimethylformamide (0.375 M, 0.4 ml, 0.15 mmol). To this solution 0.25 ml of a suspension of N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride in dichloromethane (1.73 g in 8.3 ml) was added. The mixture was shaken overnight at room temperature at 1000 rpm, added saturated NaCl (2 ml), and extracted with ethyl acetate (2×1 ml). The combined organic extracts were evaporated to afford the title compound.

1. additionwas added
2. extractionextracted with ethyl acetate (2×1 ml)
3. customThe combined organic extracts were evaporated