反应详情

19.1 g of sodium 1,1,1,3,3,3-hexamethyldisilazanate are added to a solution, cooled to −50° C., of 10 g of (4S,5S)-4-methyl-5-phenyl-3-[(2-methoxyphenyl)acetyl]oxazolidin-2-one in 150 cm3 of tetrahydrofuran, the mixture is stirred for 45 minutes at this temperature and then 7.72 cm3 of methyl iodide are added. The reaction mixture is then stirred for 15 hours at room temperature, then diluted with ethyl acetate, washed with 50 cm3 of water and then with 50 cm3 of a saturated aqueous sodium chloride solution, dried over magnesium sulphate and concentrated to dryness under reduced pressure (2.7 kPa). The residue obtained is crystallized from isopropyl ether, filtered off and dried. There are obtained 4.2 g of (4S,5S)-4-methyl-5-phenyl-3-[(S)-2-(2-methoxyphenyl)propionyl]oxazolidin-2-one in the form of a white solid.

1. stirringThe reaction mixture is then stirred for 15 hours at room temperature
2. washwashed with 50 cm3 of water
3. dry with materialwith 50 cm3 of a saturated aqueous sodium chloride solution, dried over magnesium sulphate
4. concentrationconcentrated to dryness under reduced pressure (2.7 kPa)
5. customThe residue obtained
6. customis crystallized from isopropyl ether
7. filtrationfiltered off
8. customdried