Hydrochloric Acid → HCID 86756307, compound

HRID 567665Notes

Reaction equation

HRID 567665 reaction equation
C[CH:2]1[CH2:6][S:5][CH:4]([C:7]([O:9][CH:10]([CH3:12])[CH3:11])=[O:8])[C:3]1=[N:13][OH:14].[ClH:15]>C(OC)(C)(C)C>[Cl:15][CH:2]1[CH2:6][S:5][CH:4]([C:7]([O:9][CH:10]([CH3:12])[CH3:11])=[O:8])[C:3]1=[N:13][OH:14]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86756308HCID 86756308, compound

Product 1

HCID 86756307HCID 86756307, compound

Reagents, catalysts & solvents 1

HCID 15413tert-Butyl methyl etherSolvent

Procedure

334 g (1.54 mol) of i-propyl 4-methyl-3-hydroximino-tetrahydrothiophene-2-carboxylate are dissolved in 5 litres of methyl tert-butyl ether and cooled using an ice bath. Hydrogen chloride is then—after the ice bath had been removed—introduced with stirring for two hours. The mixture is subsequently concentrated using water pump vacuum and the amorphous residue is crystallized from acetone.

Workup

  1. temperaturecooled
  2. additionhad been removed—introduced
  3. concentrationThe mixture is subsequently concentrated
  4. customthe amorphous residue is crystallized from acetone

Sources & evidence

ORD record
ord-0c86c81b47024bada760e5b2fd019c85
Source dataset
uspto-grants-2001_01
Patent number
US06180567B2

Reaction notes

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