Triethylamine → HCID 21262472, compound

HRID 567674Notes

Reaction equation

HRID 567674 reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].C(N(CC)CC)C.[F:19][C:20]1[CH:28]=[CH:27][CH:26]=[C:25]([F:29])[C:21]=1[C:22](Cl)=O>C1(C)C=CC=CC=1>[F:19][C:20]1[CH:28]=[CH:27][CH:26]=[C:25]([F:29])[C:21]=1[C:22]1[O:5][C:4](=[O:6])[C:3]2[CH:7]=[C:8]([CH3:11])[CH:9]=[CH:10][C:2]=2[N:1]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 762552-Amino-5-methylbenzoic acidHCID 874382,6-Difluorobenzoyl chloride

Product 1

HCID 21262472HCID 21262472, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

2-Amino-5-methylbenzoic acid (0.5 g) and triethyl amine (10 ml) were mixed in dry toluene (20 ml). 2,6-Difluorobenzoyl chloride (1.28 g) was added dropwise under cooling and stirring. The mixture was subsequently heated to RT for 2 days. After cooling on ice the precipitate was filtered off and the filtrate evaporated to dryness.

Workup

  1. temperatureunder cooling
  2. temperatureAfter cooling on ice the precipitate
  3. filtrationwas filtered off
  4. customthe filtrate evaporated to dryness

Sources & evidence

ORD record
ord-9b445433241d43f6845691cf73c1d29e
Source dataset
uspto-grants-2001_01
Patent number
US06180625B2

Reaction notes

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