Phthalide → HCID 70156297, compound

HRID 567716Notes

Reaction equation

HRID 567716 reaction equation
[C:1]1(=[O:10])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][O:2]1.[N:11]1[CH:16]=[CH:15][C:14]([CH:17]=O)=[CH:13][CH:12]=1>CO>[N:11]1[CH:16]=[CH:15][C:14]([CH:17]=[C:3]2[C:4]3[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=3)[C:1](=[O:10])[O:2]2)=[CH:13][CH:12]=1

Participants

4

Reactant 2

HCID 6885PhthalideHCID 133894-Pyridinecarboxaldehyde

Product 1

HCID 70156297HCID 70156297, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In accordance with the procedure described in Lombardino, J.O.C. Vol. 32, pp. 1988-1992 (1967), a solution of isobenzofuran-1-one (13.4 g, 0.1 mol) and 4-pyridine carboxaldehyde (10.7 g, 0.1 mol) in 100 ml dry methanol are refluxed for 2 hours. The solvent is evaporated, and the product (3-(4-pyridylmethylene)isobenzofuran-1-one is used in the next step without further purification.

Workup

  1. customThe solvent is evaporated
  2. customthe product (3-(4-pyridylmethylene)isobenzofuran-1-one is used in the next step without further purification

Sources & evidence

ORD record
ord-3620654cd23d420ab7f596ae0d533537
Source dataset
uspto-grants-2001_01
Patent number
US06180629B2

Reaction notes

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