2-Fluorophenyl isocyanate → HCID 15429051, compound

HRID 567726Notes

Reaction equation

HRID 567726 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]=[C:9]=[O:10].[CH3:11][O:12][C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[N:18]([CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([N+:29]([O-:31])=[O:30])[CH:24]=1)[N:17]=[C:16]2[OH:32]>O1CCCC1>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]([N:17]1[C:16](=[O:32])[C:15]2[C:19](=[CH:20][CH:21]=[C:13]([O:12][CH3:11])[CH:14]=2)[N:18]1[CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([N+:29]([O-:31])=[O:30])[CH:24]=1)=[O:10]

Participants

4

Reactant 2

HCID 855882-Fluorophenyl isocyanateHCID 178487267HCID 178487267, compound

Product 1

HCID 15429051HCID 15429051, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

1.8 g (0.013 mol) of 2-fluorophenyl isocyanate are added to a solution of 3.0 g (0.01 mol) of 5-methoxy-1-(3-nitrobenzyl)-1H-indazol-3-ol in 100 ml of tetrahydrofuran and the mixture is heated under reflux for 4 hours. It is then concentrated to 20 ml, and the precipitate deposited is filtered off with suction and recrystallized from ethyl acetate.

Workup

  1. temperaturethe mixture is heated
  2. temperatureunder reflux for 4 hours
  3. concentrationIt is then concentrated to 20 ml
  4. filtrationthe precipitate deposited is filtered off with suction
  5. customrecrystallized from ethyl acetate

Sources & evidence

ORD record
ord-7c250f40809c47f2b7e28c45e6226319
Source dataset
uspto-grants-2001_01
Patent number
US06180637B2

Reaction notes

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