Acetone → 2-{[4-(3-methoxylpropoxy)-3-methylpyridin-2-yl]methylsulfinyl}-1H-benzimidazole Sodium Salt Acetone

HRID 567790Notes

Reaction equation

[Na:1].[CH3:2][O:3][CH2:4][CH2:5][CH2:6][O:7][C:8]1[CH:13]=[CH:12][N:11]=[C:10]([CH2:14][S:15]([C:17]2[NH:21][C:20]3[CH:22]=[CH:23][CH:24]=[CH:25][C:19]=3[N:18]=2)=[O:16])[C:9]=1[CH3:26].CC(C)=O>C(OCC)(=O)C>[CH3:9][C:8]([CH3:13])=[O:7].[Na:1].[O:3]([CH2:4][CH2:5][CH2:6][O:7][C:8]1[CH:13]=[CH:12][N:11]=[C:10]([CH2:14][S:15]([C:17]2[NH:18][C:19]3[CH:25]=[CH:24][CH:23]=[CH:22][C:20]=3[N:21]=2)=[O:16])[C:9]=1[CH3:26])[CH3:2]

Participants

Conditions

Temperature: 5 °C

Procedure

2-{[4-(3-Methoxypropoxy)-3-methylpyridin-2-yl]methylsulfinyl}-1H-benzimidazole sodium salt (7.0 g) was dissolved in ethyl acetate (3 ml), and acetone (3 ml) was added thereto, and the mixture was stirred at 5° C. for 12 hours. The precipitated white crystals were filtered and dried to give the title compound (5.9 g).

Workup

filtrationThe precipitated white crystals were filtered
customdried

Sources & evidence

ORD record: ord-a5aa635aca124141ba4b7e33ee40e767
Source dataset: uspto-grants-2001_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06180652B2

Reaction notes

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