Trifluoroacetic acid → HCID 117622865, compound

HRID 56798Notes

Reaction equation

HRID 56798 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:30]#[N:31])=[C:6]([C:8]2[C:13]([O:14][CH3:15])=[CH:12][N:11]([CH:16]([CH2:24][C:25]([F:28])([F:27])[F:26])[C:17]([O:19]C(C)(C)C)=[O:18])[C:10](=[O:29])[CH:9]=2)[CH:7]=1.C(O)(C(F)(F)F)=O>ClCCl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:30]#[N:31])=[C:6]([C:8]2[C:13]([O:14][CH3:15])=[CH:12][N:11]([CH:16]([CH2:24][C:25]([F:27])([F:28])[F:26])[C:17]([OH:19])=[O:18])[C:10](=[O:29])[CH:9]=2)[CH:7]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 117622961HCID 117622961, compound

Product 1

HCID 117622865HCID 117622865, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

65.0 mg (142 μmol) of tert-butyl 2-[4-(5-chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]-4,4,4-trifluorobutanoate (racemate) in 1.6 ml of dichloromethane and 411 μl (5.34 mmol) of TFA were reacted according to General Method 6A. Yield: 53 mg (81% of theory)

Sources & evidence

ORD record
ord-615559ab84ff4a32a92fee6f3905f249
Source dataset
uspto-grants-2016_09
Patent number
US09434690B2

Reaction notes

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