Hydrochloric Acid → HCID 9944978, compound

HRID 568134Notes

Reaction equation

HRID 568134 reaction equation
[CH2:1]([N:5]1[C:14](=[O:15])[C:13]2[NH:12][C:11]([NH2:16])=[N:10][C:9]=2[N:8]([CH2:17][CH2:18][CH2:19][CH3:20])[C:6]1=[O:7])[CH2:2][CH2:3][CH3:4].Cl.C(N(CC)CC)C.[C:29](OC(=O)C)(=[O:31])[CH3:30]>C1(C)C=CC=CC=1>[CH2:1]([N:5]1[C:14](=[O:15])[C:13]2[NH:12][C:11]([NH:16][C:29](=[O:31])[CH3:30])=[N:10][C:9]=2[N:8]([CH2:17][CH2:18][CH2:19][CH3:20])[C:6]1=[O:7])[CH2:2][CH2:3][CH3:4]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 98787861.3-Di-n-butyl-8-amino xanthine

Product 1

HCID 9944978HCID 9944978, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

1.3-Di-n-butyl-8-amino xanthine (0.5 g), hydrochloride in toluene (30 ml) was stirred for 30 minutes with triethylamine (0.16 g). After addition of acetic anhydride (0.32 g), the mixture was refluxed for 6 hours. The reaction mixture was extracted with water (4×30 ml), the organic layer separated and dried over anhydrous sodium sulphate. The solvent was then evaporated to yield the product, yield 0.1 g (20%), mpt. 180° C.

Workup

  1. temperaturethe mixture was refluxed for 6 hours
  2. extractionThe reaction mixture was extracted with water (4×30 ml)
  3. customthe organic layer separated
  4. dry with materialdried over anhydrous sodium sulphate
  5. customThe solvent was then evaporated
  6. customto yield the product, yield 0.1 g (20%), mpt
  7. custom180° C.

Sources & evidence

ORD record
ord-f088e6d543834e3a80f22f10f2cc70e2
Source dataset
uspto-grants-2001_01
Patent number
US06180791B2

Reaction notes

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