Lithium Hydroxide → HCID 131736945, compound

HRID 56830Notes

Reaction equation

[Si:1]([O:8][CH:9]1[CH2:14][CH2:13][CH:12]([CH2:15][CH:16]([N:24]2[CH:29]=[C:28]([O:30][CH3:31])[C:27]([C:32]3[CH:37]=[C:36]([Cl:38])[CH:35]=[CH:34][C:33]=3[C:39]#[N:40])=[CH:26][C:25]2=[O:41])[C:17]([O:19]C(C)(C)C)=[O:18])[CH2:11][CH2:10]1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[OH-].[Li+]>>[Si:1]([O:8][CH:9]1[CH2:10][CH2:11][CH:12]([CH2:15][CH:16]([N:24]2[CH:29]=[C:28]([O:30][CH3:31])[C:27]([C:32]3[CH:37]=[C:36]([Cl:38])[CH:35]=[CH:34][C:33]=3[C:39]#[N:40])=[CH:26][C:25]2=[O:41])[C:17]([OH:19])=[O:18])[CH2:13][CH2:14]1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 131736944HCID 131736944, compound

Product 1

HCID 131736945HCID 131736945, compound

Procedure

479 mg (797 μmol) of tert-butyl 3-(4-{[tert-butyl(dimethyl)silyl]oxy}cyclohexyl)-2-[4-(5-chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]propanoate (mixture of two racemic diastereomers) were reacted with 4 ml of aqueous lithium hydroxide solution (1N) according to General Method 6B, giving the title compound. Yield: 400 mg (80% of theory)

Sources & evidence

ORD record: ord-07f9b26192f142d989f0f3e523c2a3a4
Source dataset: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09434690B2

Reaction notes

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