N-methyl-2-pyrrolidone → 4-(4-Amino-3-cyano-5-trifluoromethylphenyl)-1,2,4-triazole

HRID 568397Notes

Reaction equation

HRID 568397 reaction equation
[NH2:1][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][C:5]([N:12]2[CH:16]=[N:15][N:14]=[CH:13]2)=[CH:4][C:3]=1Br.[CH3:18][N:19]1CCCC1=O>>[NH2:1][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][C:5]([N:12]2[CH:16]=[N:15][N:14]=[CH:13]2)=[CH:4][C:3]=1[C:18]#[N:19]

Participants

3

Reactant 2

HCID 13387N-methyl-2-pyrrolidoneHCID 198670724-(4-Amino-3-bromo-5-trifluoromethylphenyl)-1,2,4-triazole

Product 1

HCID 198670734-(4-Amino-3-cyano-5-trifluoromethylphenyl)-1,2,4-triazole

Procedure

The following compound, m.p. 283°, was similarly prepared to the previous Preparation using 4-(4-amino-3-bromo-5-trifluoromethylphenyl)-1,2,4-triazole, cuprous cyanide and 1-methyl-2-pyrrolidone as the starting materials: ##STR148##

Workup

  1. customThe following compound, m.p. 283°, was similarly prepared to the previous Preparation

Sources & evidence

ORD record
ord-2e4b9094d47b4ff6a968487510e3b2d5
Source dataset
uspto-grants-1988_03
Patent number
US04728653

Reaction notes

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