1-Fluoro-2-nitrobenzene → HCID 14626470, compound

HRID 568598Notes

Reaction equation

HRID 568598 reaction equation
F[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9].[F:11][C:12]1[CH:13]=[C:14]([CH:17]=[C:18]([F:22])[C:19]=1[O:20][CH3:21])[CH2:15][NH2:16].C([O-])(=O)C.[NH4+]>>[F:11][C:12]1[CH:13]=[C:14]([CH:17]=[C:18]([F:22])[C:19]=1[O:20][CH3:21])[CH2:15][NH:16][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9]

Participants

4

Reactant 3

HCID 738951-Fluoro-2-nitrobenzeneHCID 517165Ammonium AcetateHCID 146264691-(3,5-Difluoro-4-methoxyphenyl)methanamine

Product 1

HCID 14626470HCID 14626470, compoundYield 100%

Procedure

A mixture of 2-fluoronitrobenzene (0.82 g, 5.8 mmole), 3,5-difluoro-4-methoxybenzylamine, (3.0 g, 17.3 mmole) and ammonium acetate (0.5 g) was reacted substantially as described in 1C above to yield 1.7 g, (100%) of the title compound as orange crystals.

Workup

  1. customwas reacted substantially

Sources & evidence

ORD record
ord-fbb3d18245cb4a8f9a85ff3579a82b51
Source dataset
uspto-grants-1988_03
Patent number
US04728741

Reaction notes

Loading…