Water → HCID 14012541, compound

HRID 568716Notes

Reaction equation

HRID 568716 reaction equation
C(O/[N:5]=[C:6](/[C:16]1[CH:21]=[C:20]([F:22])[CH:19]=[CH:18][C:17]=1[F:23])\[C:7]1[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[CH:9][C:8]=1[OH:15])(=O)C.C(=O)([O-])[O-].[K+].[K+].O>CN(C)C=O>[F:23][C:17]1[CH:18]=[CH:19][C:20]([F:22])=[CH:21][C:16]=1[C:6]1[C:7]2[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[CH:9][C:8]=2[O:15][N:5]=1

Participants

5

Reactant 3

HCID 962WaterHCID 11430Potassium CarbonateHCID 136477422HCID 136477422, compound

Product 1

HCID 14012541HCID 14012541, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a mixture of 34 g of E-2',5'-difluoro-2-hydroxy-4-methoxybenzophenone O-acetyl oxime in 70 ml dimethylformamide at 65° C., 18.2 g of potassium carbonate is added. The mixture is stirred for 45 min and poured into water. The precipitate is collected and dried. Recrystallization from ether gives 3-(2,5-difluorophenyl)-6-methoxy-1,2-benzisoxazole, mp 121°-122° C.

Workup

  1. customThe precipitate is collected
  2. customdried
  3. customRecrystallization from ether

Sources & evidence

ORD record
ord-c22934f3f5e34707b337447a0169d586
Source dataset
uspto-grants-1988_03
Patent number
US04728662

Reaction notes

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