反应详情

A mixture of ethyl 2-hydroxyimino-2-propionylacetate (10.7 g.), potassium carbonate (9.8 g.), dimethyl sulfate (7.79 g.) and ethyl acetate (70 ml.) was stirred at room temperature for an hour. Water (50 ml.) was added to the reaction mixture and stirred for 20 minutes. The ethyl acetate layer was separated, washed with water (50 ml.) twice and with an aqueous solution of sodium chloride, dried over magnesium sulfate and then filtered. The filtrate was evaporated in vacuo to give ethyl 2-methoxyimino-2-propionylacetate (14.7 g.).

1. stirringstirred for 20 minutes
2. customThe ethyl acetate layer was separated
3. washwashed with water (50 ml.) twice
4. dry with materialwith an aqueous solution of sodium chloride, dried over magnesium sulfate
5. filtrationfiltered
6. customThe filtrate was evaporated in vacuo