Trifluoroacetic acid → HCID 86742034, compound

HRID 568962Notes

Reaction equation

HRID 568962 reaction equation
[CH3:1][O:2][C:3](=[O:8])[C:4]([F:7])([F:6])[F:5].FC(F)(F)[C:11](O)=[O:12]>CO>[CH3:1][O:2][C:3](=[O:8])[C:4]([F:7])([F:6])[F:5].[CH3:11][OH:12]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 9893Methyl trifluoroacetate

Product 1

HCID 86742034HCID 86742034, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A process for the preparation of methyltrifluoroacetate. Trifluoroacetic acid is contacted with an excess of methanol and distilled to form a methyltrifluoroacetate/methanol azeotrope. The azeotrope is contacted with trifluoroacetic acid in the presence of a catalytic quantity of a strong acid followed by distillation to obtain methyltrifluoroacetate. The methyltrifluoroacetate can be used as a synthesis intermediate in the pharmaceutical industry.

Workup

  1. distillationdistilled

Sources & evidence

ORD record
ord-97f6c309e0234511960d32f967ac49a9
Source dataset
uspto-grants-1988_03
Patent number
US04730082

Reaction notes

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