HCID 20149456, compound → HCID 18611972, compound

HRID 568988Notes

Reaction equation

HRID 568988 reaction equation
C(OC([NH:8][CH:9]([C:13]([F:29])([F:28])[CH2:14][CH2:15][CH:16]([NH:20]C(OC(C)(C)C)=O)[C:17]([OH:19])=[O:18])[C:10]([OH:12])=[O:11])=O)(C)(C)C>CCOCC.Cl>[F:28][C:13]([F:29])([CH:9]([C:10]([OH:12])=[O:11])[NH2:8])[CH2:14][CH2:15][C@@H:16]([C:17]([OH:19])=[O:18])[NH2:20]

Participants

4

Reactant 1

HCID 20149456HCID 20149456, compound

Product 1

HCID 18611972HCID 18611972, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 3283Diethyl EtherSolvent

Procedure

2,6-di-t-butoxycarbonylamino-3,3-difluoro-1,7-heptanedioic acid (34 mg, 0.08 mmoles) is dissolved in dry ether saturated with HCl gas. After standing overnight and filtration, the title compound is obtained as a white solid (9 mg, 38%, RF: 0.4 (ethanol, conc. ammonia: 70/30, RF: 0.1 (butanol/acetic acid/water: 4/2/2)

Workup

  1. filtrationfiltration

Sources & evidence

ORD record
ord-6057e4b3b0d24b099b4a930858192e39
Source dataset
uspto-grants-1988_03
Patent number
US04730006

Reaction notes

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