Sodium hydride → HCID 13315114, compound

HRID 569025Notes

Reaction equation

HRID 569025 reaction equation
[CH2:1]([O:8][C:9]([C:11]1[CH:12]=[C:13]2[C:21](=[CH:22][CH:23]=1)[NH:20][C:19]1[CH:18]=[N:17][C:16]([S:24]([CH3:26])=[O:25])=[CH:15][C:14]2=1)=[O:10])[C:2]1C=CC=CC=1.[H-].[Na+]>C(O)C>[CH2:1]([O:8][C:9]([C:11]1[CH:12]=[C:13]2[C:21](=[CH:22][CH:23]=1)[NH:20][C:19]1[CH:18]=[N:17][C:16]([S:24]([CH3:26])=[O:25])=[CH:15][C:14]2=1)=[O:10])[CH3:2]

Participants

4

Reactant 2

HCID 24758Sodium hydrideHCID 13315113HCID 13315113, compound

Product 1

HCID 13315114HCID 13315114, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

270 mg of 6-benzyloxycarbonyl-3-methylsulfinyl-β-carboline are refluxed for 1.5 hours with an alcoholate solution prepared from 27 mg 80% sodium hydride and 15 ml of absolute ethanol. After concentration, it is picked up in ethyl acetate and suctioned off. 78 mg of 6-ethoxycarbonyl-3-methylsulfinyl-β-carboline with a 240°-243° C. melting point are obtained.

Workup

  1. concentrationAfter concentration, it
  2. customwith a 240°-243° C.
  3. customare obtained

Sources & evidence

ORD record
ord-786aa1112cf9422889c5516c779b509f
Source dataset
uspto-grants-1988_03
Patent number
US04731358

Reaction notes

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