Ethanol → HCID 13315133, compound

HRID 569037Notes

Reaction equation

HRID 569037 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]2[C:14](=[CH:15][CH:16]=1)[NH:13][C:12]1[CH:11]=[N:10][C:9]([S:17][CH3:18])=[CH:8][C:7]2=1)([O-])=O.C(O)C>O1CCCC1.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]2[C:14](=[CH:15][CH:16]=1)[NH:13][C:12]1[CH:11]=[N:10][C:9]([S:17][CH3:18])=[CH:8][C:7]2=1

Participants

5

Reactant 2

HCID 702EthanolHCID 13315132HCID 13315132, compound

Product 1

HCID 13315133HCID 13315133, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

950 mg of 6-nitro-3-methylthio-β-carboline are hydrogenated in 80 ml of tetrahydrofuran and 80ml of ethanol with 200 mg of palladium/carbon (10%) for 7.5 hours at room temperature under normal hydrogen pressure. After filtration and concentration, the residue is chromatographed on silica gel with methylene chloride/acetone=1:1 as eluant. 600 mg of 6-amino-3-methylthio-β-carboline with a 202° C. melting point are obtained.

Workup

  1. filtrationAfter filtration and concentration
  2. customthe residue is chromatographed on silica gel with methylene chloride/acetone=1:1 as eluant
  3. customwith a 202° C.
  4. customare obtained

Sources & evidence

ORD record
ord-bc95d0d624634db2ba3d00a8b5ca8667
Source dataset
uspto-grants-1988_03
Patent number
US04731358

Reaction notes

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