反应详情

To a solution of tert-butyl 2-methoxycarbonylmethoxyimino-3-oxobutyrate (syn isomer) (10 g) in glacial acetic acid (5 ml) was added 30% hydrobromic acid in acetic acid (10 ml) at ambient temperature with stirring. The reaction mixture was stirred at 40° C. for 3 hours. The resultant solution was concentrated under reduced pressure and the residual oil was dissolved into ethyl acetate (100 ml). The ethyl acetate layer was washed with a saturated aqueous solution of sodium chloride four times and dried over magnesium sulfate. The solvent was evaporated under reduced pressure to give a crude oil (8.6 g). The oil was dissolved in methylene chloride (100 ml). To the solution was added potassium carbonate (1.87 g) and the suspension was stirred at ambient temperature for 30 minutes. The solution was diluted with n-hexane (100 ml). The solvent was decanted and the residual glassy mass was dissolved in ethyl acetate and 10% hydrochloric acid. The separated organic layer was washed with a saturated aqueous solution of sodium chloride and dried over magnesium sulfate. The solvent was concentrated under reduced pressure to give 2-methoxycarbonylmethoxyimino-3-oxobutyric acid (syn isomer) (4.0 g) as an oil.

1. stirringThe reaction mixture was stirred at 40° C. for 3 hours
2. concentrationThe resultant solution was concentrated under reduced pressure
3. dissolutionthe residual oil was dissolved into ethyl acetate (100 ml)
4. washThe ethyl acetate layer was washed with a saturated aqueous solution of sodium chloride four times
5. dry with materialdried over magnesium sulfate
6. customThe solvent was evaporated under reduced pressure
7. customto give a crude oil (8.6 g)
8. stirringthe suspension was stirred at ambient temperature for 30 minutes
9. customThe solvent was decanted
10. dissolutionthe residual glassy mass was dissolved in ethyl acetate
11. washThe separated organic layer was washed with a saturated aqueous solution of sodium chloride
12. dry with materialdried over magnesium sulfate
13. concentrationThe solvent was concentrated under reduced pressure