HCID 14099741, compound → HCID 14099743, compound

HRID 569467Notes

Reaction equation

HRID 569467 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][C:15]([C:17]3[N:18]=[C:19]([C:23]4[CH:24]=[N:25][CH:26]=[CH:27][CH:28]=4)[NH:20][C:21]=3[CH3:22])=[O:16])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1>O1CCCC1.C1([Mg]Br)C=CC=CC=1.CCOCC>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH2:9][CH2:10][N:11]([CH2:14][C:15]([C:17]3[N:18]=[C:19]([C:23]4[CH:24]=[N:25][CH:26]=[CH:27][CH:28]=4)[NH:20][C:21]=3[CH3:22])([C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)[OH:16])[CH2:12][CH2:13]2)=[CH:6][CH:7]=1

Participants

5

Reactant 1

HCID 14099741HCID 14099741, compound

Product 1

HCID 14099743HCID 14099743, compoundYield 82.9%

Reagents, catalysts & solvents 3

HCID 3283Diethyl EtherSolventHCID 8028TetrahydrofuranSolventHCID 178418255HCID 178418255, compoundSolvent

Procedure

A mixture of 1.5 g of 2-[4-(4-fluorophenyl)-1-piperazinyl]-1-[5-methyl-2-(3-pyridinyl)-1H-imidazol-4-yl]ethanone in 20 ml of dry tetrahydrofuran and 10 ml of 1.7M phenyl magnesium bromide in 10 ml of ether was reacted as described in Example 41 giving 2 g of a foam. This foam was purified by chromatography, giving 0.75 g of the desired product as a light yellow foam.

Workup

  1. customwas reacted
  2. customThis foam was purified by chromatography

Sources & evidence

ORD record
ord-f70fe9d9aa5f48808b121aec8d3ee4c6
Source dataset
uspto-grants-1988_03
Patent number
US04732895

Reaction notes

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