Hydrochloric Acid → HCID 14152229, compound

HRID 569701Notes

Reaction equation

HRID 569701 reaction equation
[CH3:1][O-:2].[Na+].CO.[Na].[Cl:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([Cl:14])[C:9]=1[NH:15][S:16]([C:19]1[N:29]=[C:22]2[N:23]=[C:24]([CH3:28])[CH:25]=[C:26](Cl)[N:21]2[N:20]=1)(=[O:18])=[O:17].Cl>CO.C(Cl)Cl.CO>[Cl:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([Cl:14])[C:9]=1[NH:15][S:16]([C:19]1[N:29]=[C:22]2[N:23]=[C:24]([CH3:28])[CH:25]=[C:26]([O:2][CH3:1])[N:21]2[N:20]=1)(=[O:18])=[O:17]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 5360545SodiumHCID 14152228HCID 14152228, compoundHCID 23694274Sodium methanolate methanol

Product 1

HCID 14152229HCID 14152229, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 21226129Dichloromethane methanolSolvent

Procedure

A sodium methoxide-methanol solution was made by dissolving 0.3 g (13 mg-atom) of sodium metal into 20 ml of absolute methanol. To this solution was added 1.0 g (2.5 mmol) of N-(2,6-dichlorophenyl)-7-chloro-5-methyl-1,2,4-triazolo-[1,5-a]pyrimidine-2-sulfonamide. A mild exotherm ensued and the reaction was complete within 10 min as determined by TLC (20 percent methanol-methylene chloride). The solution was acidified with 6N aqueous HCl and the resulting white solid collected. Recovered 0.9 g (93 percent) of a white powder; mp 214°-215° C.

Workup

  1. customthe resulting white solid collected
  2. customRecovered 0.9 g (93 percent) of a white powder

Sources & evidence

ORD record
ord-a79b8d582f0c429cbafd59863be2f235
Source dataset
uspto-grants-1988_03
Patent number
US04734123

Reaction notes

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