Tetrahydrofuran → 2,1-Benzisothiazole-6-carboxaldehyde

HRID 569746Notes

Reaction equation

HRID 569746 reaction equation
[OH:1][CH2:2][C:3]1[CH:11]=[CH:10][C:6]2=[CH:7][S:8][N:9]=[C:5]2[CH:4]=1.O1CCCC1>C(Cl)Cl.[O-2].[Mn+4].[O-2]>[N:9]1[S:8][CH:7]=[C:6]2[CH:10]=[CH:11][C:3]([CH:2]=[O:1])=[CH:4][C:5]=12

Participants

5

Reactant 2

HCID 8028TetrahydrofuranHCID 201462422,1-Benzisothiazole-6-methanol

Product 1

HCID 201462602,1-Benzisothiazole-6-carboxaldehyde

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

1.65 g (10 mmol) of 10b are stirred analogously to Example 1b in 100 ml of CH2Cl2 and 30 ml of tetrahydrofuran with 5.5 g (63.4 mmol) of manganese(IV) oxide at room temperature overnight.

Workup

  1. customat room temperature
  2. customovernight

Sources & evidence

ORD record
ord-e42d5361e2b241298e430638130ab6a6
Source dataset
uspto-grants-1988_03
Patent number
US04734407

Reaction notes

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