反应详情

2.5 Grams of 1-benzyl-5-hydroxy-3,4-dihydrocarbostyril and 0.48 g of 50% oily NaH are mixed with 30 ml of dimethyl formamide and stirred, then 4 g of 1-chloro-3-(4-phenylpiperazinyl)propane are added thereinto and warmed to 50°-60° C. for 2.5 hours. The reaction mixture is concentrated under a reduced pressure and the residue thus obtained is extracted with chloroform. After removing the chloroform by distillation, the thus obtained residue is recrystallized from ligroin to obtain 2.1 g of 1-benzyl-5-[3-(4-phenylpiperazinyl)propoxy]-3,4-dihydrocarbostyril in the form of pale yellowish needle-like crystals with a melting point of 113° C.

1. temperaturewarmed to 50°-60° C. for 2.5 hours
2. concentrationThe reaction mixture is concentrated under a reduced pressure
3. customthe residue thus obtained
4. extractionis extracted with chloroform
5. customAfter removing the chloroform
6. distillationby distillation
7. customthe thus obtained residue is recrystallized from ligroin