Hydrogen Bromide → Hydrogen Bromide

HRID 569984Notes

Reaction equation

HRID 569984 reaction equation
[CH2:1](OC(N1CCN(C2N=CC3C(=O)N(CC)C=C(C=O)C=3N=2)CC1)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[BrH:32]>C(O)(=O)C>[BrH:32].[CH2:1]([Br:32])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 260Hydrogen BromideHCID 13650240HCID 13650240, compound

Product 2

HCID 260Hydrogen BromideHCID 7498Benzyl Bromide

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Procedure

Dissolved in a 25% hydrogen bromide solution of acetic acid was 0.2 g of the 2-(4-benzyloxycarbonylpiperazino)-5,6-dihydro-6-ethyl-5-oxopyrido[4,3-d]pyrimidine-8-carbaldehyde obtained in Referential Example 20. The resulting mixture was stirred at room temperature for 1 hour. Hydrogen bromide, acetic acid and resulting benzyl bromide were distilled off under reduced pressure. After neutralizing the residue with a saturated aqueous solution of sodium carbonate, the mixture was extracted with chloroform and the chloroform layer was dried with anhydrous magnesium sulfate. Chloroform was distilled off under reduced pressure to obtain 0.13 g of light yellowish crystals (yield: 95%).

Workup

  1. customobtained in Referential Example 20

Sources & evidence

ORD record
ord-b447e713bf914fa6956ac1243b9f1ce7
Source dataset
uspto-grants-1988_03
Patent number
US04734418

Reaction notes

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