Acetone → HCID 67906105, compound

HRID 569998Notes

Reaction equation

HRID 569998 reaction equation
CC(C)=O.[CH2:5]([N:12]1[CH2:17][CH2:16][N:15]([C:18]2[N:27]=[CH:26][C:25]3[C:24](=[N:28]O)[CH2:23][CH2:22][CH2:21][C:20]=3[N:19]=2)[CH2:14][CH2:13]1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[C:30]1([CH3:40])[CH:35]=[CH:34][C:33]([S:36](Cl)(=[O:38])=[O:37])=[CH:32][CH:31]=1.[OH-].[K+]>O>[CH2:5]([N:12]1[CH2:17][CH2:16][N:15]([C:18]2[N:27]=[CH:26][C:25]3[C:24](=[N:28][S:36]([C:33]4[CH:34]=[CH:35][C:30]([CH3:40])=[CH:31][CH:32]=4)(=[O:38])=[O:37])[CH2:23][CH2:22][CH2:21][C:20]=3[N:19]=2)[CH2:14][CH2:13]1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

Participants

6

Reactant 4

HCID 180AcetoneHCID 73974-Toluenesulfonyl chlorideHCID 14797Potassium HydroxideHCID 73187455HCID 73187455, compound

Product 1

HCID 67906105HCID 67906105, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Added to a mixture of 30 ml of acetone, 2 g (5.35 mmol, Referential Example 49) of 2-(4-benzylpiperazino)-5,6,7,8-tetrahydro-5-hydroxyiminoquinazoline, and 1.6 g (8.4 mmol) of p-toluenesulfonyl chloride was a solution of 0.7 g (11 mmol) of KOH in 10 ml of water. The resultant mixture was stirred at 20° C. for 4 hours.

Sources & evidence

ORD record
ord-79fe383db0614223b01c6c5291078e2b
Source dataset
uspto-grants-1988_03
Patent number
US04734418

Reaction notes

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