反应详情

温度

0 °C

200 mg (0.77 mmol) of 1-(2-fluorobenzyl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboximidamide were initially charged in 4 ml of ethanol and cooled to 0° C. 310 mg (3.07 mmol) of triethylamine and 48 mg (0.77 mmol) of 80% hydrazine hydrate were added, and the mixture was stirred at room temperature for 72 h. The mixture was concentrated on a rotary evaporator, taken up in ethyl acetate and washed three times with saturated aqueous sodium chloride solution. The organic phase was dried over sodium sulphate, concentrated on a rotary evaporator and dried under high vacuum. 209 mg (100% of theory) of the target compound were obtained.

1. concentrationThe mixture was concentrated on a rotary evaporator
2. washwashed three times with saturated aqueous sodium chloride solution
3. dry with materialThe organic phase was dried over sodium sulphate
4. concentrationconcentrated on a rotary evaporator
5. customdried under high vacuum
6. custom209 mg (100% of theory) of the target compound were obtained