Trifluoroacetic acid → HCID 10821490, compound

Temperature

-40 °C

N-(t-Boc)-4-Methoxy-2-methylaniline (1.00 g, 4.2 mmol) was dissolved in THF (15 mL) under an atmosphere of Ar (g). The solution was cooled to −40° C. over 10 minutes and sec-butyllithium (1.4 M in cyclohexane, 6.66 mL) was added slowly to maintain an internal temperature of <−25° C. After reaching 1 equivalent of sec-butyllithium (3.33 mL) the reaction mixture turned a bright yellow signifying the total deprotonation of the amide nitrogen. The reaction mixture was then cooled to −50° C. and a solution of N-methoxy-N-methylbutanamide (580 mg, 4.4 mmol) in THF (3 mL) was added over 10 minutes in a dropwise fashion. The reaction mixture was warmed to −10° C. over 30 minutes. The mixture was partitioned between Et2O (50 mL) and 1 N HCl (50 mL). The aqueous layer was extracted an additional two times with Et2O (25 mL). The organic layer was washed with brine (50 mL), dried over anhydrous Na2SO4 and concentrated in vacuo to yield a brown solid. This above reaction was performed twice yielding crude brown solid (3 g), which was taken directly to the next step. Crude product (3 g) was dissolved in dichloromethane (20 mL) and trifluoroacetic acid (3 mL) was added to the solution and the reaction mixture was stirred at room temperature for 48 hours. When the reaction reached completion, the reaction mixture was added to a separatory funnel and washed with NaHCO3 (30 mL) followed by brine (30 mL). The organic layer was dried over NaSO4 and concentrated in vacuo giving a crude black oil (3.03 g) which was purified with column chromatography to yield a yellow/brown solid (1.1 g, 68%): TLC Rf 0.32 in 10% EtOAc/hexanes. Melting point=64-65° C. 1H NMR (600 MHz, CDCl3) δ 7.74 (s, 1H), 7.19-7.17 (d, 1H, J=8.7 Hz), 7.01 (d, 1H, J=2.46 Hz), 6.78-6.76 (dd, 1H J1=8.7 Hz, J2=2.46 Hz) 6.18-6.17 (m, 1H), 3.84 (s, 3H), 2.72-2.70 (t, 2H, J=7.34 Hz), 1.77-1.71 (m, 2H), 1.01-0.99 (t, 3H, J=7.32 Hz); 13C NMR (150 MHz, CDCl3) δ 154.3, 140.9, 131.1, 129.5, 111.08, 110.96, 102.16, 99.7, 56.1, 30.6, 22.7, 14.1. Elemental analysis calculated for C12H15NO: C, 76.16; H, 7.99; N, 7.40. Found: C, 76.28; H, 7.97; N, 7.39.

1. temperatureto maintain an internal temperature of <−25° C
2. temperatureThe reaction mixture was then cooled to −50° C.
3. temperatureThe reaction mixture was warmed to −10° C. over 30 minutes
4. customThe mixture was partitioned between Et2O (50 mL) and 1 N HCl (50 mL)
5. extractionThe aqueous layer was extracted an additional two times with Et2O (25 mL)
6. washThe organic layer was washed with brine (50 mL)
7. dry with materialdried over anhydrous Na2SO4
8. concentrationconcentrated in vacuo
9. customto yield a brown solid
10. customThis above reaction
11. customwas performed twice yielding crude brown solid (3 g), which
12. additionthe reaction mixture was added to a separatory funnel
13. washwashed with NaHCO3 (30 mL)
14. dry with materialThe organic layer was dried over NaSO4
15. concentrationconcentrated in vacuo
16. customgiving a crude black oil (3.03 g) which
17. customwas purified with column chromatography

ORD record

ord-666a5e6cf6ea4f759697a97bcff90a8a

Source dataset

uspto-grants-2015_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09023871B2