Pyridinium chloride → HCID 86685396, compound

HRID 570740Notes

Reaction equation

HRID 570740 reaction equation
[CH2:1]([S:3][C:4]1[N:13]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH2:21][C:22]([F:25])([F:24])[F:23])=[CH:16][CH:15]=2)[C:12](=[O:26])[C:11]2[C:6](=[N:7][C:8]([O:27]C)=[CH:9][N:10]=2)[N:5]=1)[CH3:2].Cl.N1C=CC=CC=1>CN(C)C=O>[CH2:1]([S:3][C:4]1[N:13]([C:14]2[CH:15]=[CH:16][C:17]([O:20][CH2:21][C:22]([F:23])([F:25])[F:24])=[CH:18][CH:19]=2)[C:12](=[O:26])[C:11]2[N:10]=[CH:9][C:8](=[O:27])[NH:7][C:6]=2[N:5]=1)[CH3:2]

Participants

4

Reactant 2

HCID 10176127Pyridinium chlorideHCID 68015340HCID 68015340, compound

Product 1

HCID 86685396HCID 86685396, compoundYield 56.3%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
120 °C

Procedure

A mixture of 2-(ethylsulfanyl)-7-methoxy-3-[4-(2,2,2-trifluoroethoxy)phenyl]pteridin-4(3H)-one (92 mg), pyridine hydrochloride (640 mg) and N,N-dimethylformamide (3 ml) was stirred at 120° C. for 10 hr, and in the same manner as in Example 6, the title compound (50 mg) was obtained as a white powder.

Sources & evidence

ORD record
ord-56402f15807146eca4d5f3a24045af90
Source dataset
uspto-grants-2015_05
Patent number
US09023858B2

Reaction notes

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