Ethyl cyanoacetate → HCID 367060, compound

HRID 570822Notes

Reaction equation

HRID 570822 reaction equation
[CH2:1]([O:3][C:4](=[O:8])[CH2:5][C:6]#[N:7])[CH3:2].[F:9][C:10]1[CH:11]=[C:12]([CH:15]=[CH:16][CH:17]=1)[CH:13]=O>C(O)C.N1CCCC1>[CH2:1]([O:3][C:4](=[O:8])[C:5]([C:6]#[N:7])=[CH:13][C:12]1[CH:15]=[CH:16][CH:17]=[C:10]([F:9])[CH:11]=1)[CH3:2]

Participants

5

Reactant 2

HCID 7764Ethyl cyanoacetateHCID 680093-Fluorobenzaldehyde

Product 1

HCID 367060HCID 367060, compoundYield 98.5%

Reagents, catalysts & solvents 2

HCID 31268PyrrolidineCatalystHCID 702EthanolSolvent

Procedure

A solution of cyanoacetic acid ethyl ester (1.1 g), 3-fluorobenzaldehyde (1.5 g) and pyrrolidine (0.043 g) in ethanol (10 mL) was stirred at room temperature for 2 hours. The precipitated solid was collected by filtration, and this obtained solid was washed with ethanol (40 mL) to give the title compound (2.1 g).

Workup

  1. filtrationThe precipitated solid was collected by filtration
  2. washthis obtained solid was washed with ethanol (40 mL)

Sources & evidence

ORD record
ord-55f9db3ceccb48269777f29020aab8d2
Source dataset
uspto-grants-2015_05
Patent number
US09023882B2

Reaction notes

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