Hydrochloric Acid → HCID 89601303, compound

HRID 570916Notes

Reaction equation

HRID 570916 reaction equation
[C:1]([N:4]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[N:5]1[CH2:10][C:9]([CH:11]=O)=[N:8][N:7]([C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[C:6]1=[O:20])(=[O:3])[CH3:2].[CH3:28][N:29]([CH3:31])[NH2:30].Cl>CCO>[C:1]([N:4]([C:21]([O:23][C:24]([CH3:26])([CH3:25])[CH3:27])=[O:22])[N:5]1[CH2:10][C:9](/[CH:11]=[N:30]/[N:29]([CH3:31])[CH3:28])=[N:8][N:7]([C:13]([O:15][C:16]([CH3:17])([CH3:18])[CH3:19])=[O:14])[C:6]1=[O:20])(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 59761,1-DimethylhydrazineHCID 89601756HCID 89601756, compound

Product 1

HCID 89601303HCID 89601303, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of tert-butyl 4-[acetyl(tert-butoxycarbonyl)amino]-6-formyl-3-oxo-5H-1,2,4-triazine-2-carboxylate (461 mg, 1.20 mmol) in EtOH was added N,N-dimethylhydrazine (0.110 mL, 1.44 mmol), followed by addition of 1 droplet of conc. HCl. The mixture was stirred at room temperature for 20 h followed by evaporation of the volatiles to give the title compound as a viscous oil. LCMS (Method K) RT 0.99 min. [M+H]+ 427.

Workup

  1. customfollowed by evaporation of the volatiles

Sources & evidence

ORD record
ord-624d3b0a2a514f2a8789d28064e56325
Source dataset
uspto-grants-2015_05
Patent number
US09024019B2

Reaction notes

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