Hydrogen iodide → HCID 178456698, compound

HRID 570947Notes

Reaction equation

HRID 570947 reaction equation
I.[O:2]=[C:3]1[N:8]([CH2:9][C:10]#[CH:11])[N:7]=[N:6][C:5]2=[C:12]([C:15](=[NH:26])[NH:16][CH2:17][C:18](=O)[C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[N:13]=[CH:14][N:4]12.I>Cl>[C:19]1([C:18]2[N:26]=[C:15]([C:12]3[N:13]=[CH:14][N:4]4[C:3](=[O:2])[N:8]([CH2:9][C:10]#[CH:11])[N:7]=[N:6][C:5]=34)[NH:16][CH:17]=2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

4

Reactant 2

HCID 24841Hydrogen iodideHCID 178456701HCID 178456701, compound

Product 1

HCID 178456698HCID 178456698, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent2×

Conditions

Temperature
80 °C

Procedure

A mixture of crude 4-oxo-N-(2-oxo-2-phenylethyl)-3-(prop-2-ynyl)-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboximidamide hydroiodide (45 mg) in 3N HCl (4 mL) was heated at 80° C. overnight. After being cooled to room temperature, the mixture was left at 4° C. for 2 hours and the precipitate was filtered and washed successively with cold water, ethyl acetate and diethyl ether to give a mixture of the hydrochloride and hydroiodide salts of the title compound.

Workup

  1. temperatureAfter being cooled to room temperature
  2. filtrationthe precipitate was filtered
  3. washwashed successively with cold water, ethyl acetate and diethyl ether
  4. customto give

Sources & evidence

ORD record
ord-610222cf550e477a95a04448054d7917
Source dataset
uspto-grants-2015_05
Patent number
US09024018B2

Reaction notes

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