Dicyclohexylcarbodiimide → N,N'-Dicyclohexylurea

HRID 570990Notes

Reaction equation

HRID 570990 reaction equation
FC(F)(F)C(NCC1C=CC=CC=1C(O)=O)=[O:4].[CH:18]1([N:24]=[C:25]=[N:26][CH:27]2[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]2)[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1>O1CCCC1>[C:25]([NH:24][CH:18]1[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]1)([NH:26][CH:27]1[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1)=[O:4]

Participants

4

Reactant 2

HCID 10868DicyclohexylcarbodiimideHCID 54150269HCID 54150269, compound

Product 1

HCID 4277N,N'-Dicyclohexylurea

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Weighed into a 10 ml round-bottomed flask were 593 mg (2.4 mmol) of trifluoroacetamidomethyl benzoic acid. This acid was dissolved in 4 ml of anhydrous tetrahydrofuran and 324.4 mg (1.2 mmol) of 1,3-dicyclohexylcarbodiimide were added. It was left stirring, at ambient temperature, for 2 hours. The white precipitate of dicyclohexylurea obtained was filtered over a frit.

Workup

  1. customWeighed into a 10 ml round-bottomed flask were
  2. waitIt was left

Sources & evidence

ORD record
ord-fa89c8522004482dafdce69bfce28cb6
Source dataset
uspto-grants-2015_05
Patent number
US09024022B2

Reaction notes

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