Hydrochloric Acid → HCID 86681654, compound

HRID 571237Notes

Reaction equation

HRID 571237 reaction equation
[CH3:1][S:2]([NH:5][C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[N:11]([CH2:15][C:16]([O:18]C)=[O:17])[C:10](=[O:20])[CH2:9]2)(=[O:4])=[O:3].Cl>O1CCOCC1>[CH3:1][S:2]([NH:5][C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[N:11]([CH2:15][C:16]([OH:18])=[O:17])[C:10](=[O:20])[CH2:9]2)(=[O:3])=[O:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86681653HCID 86681653, compound

Product 1

HCID 86681654HCID 86681654, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of methyl 2-(5-(methylsulfonamido)-2-oxoindolin-1-yl)acetate (0.133 g, 0.446 mmol) in dioxane (5 ml), 12M HCl (4 ml, 48.0 mmol) was added, and the mixture was stirred at room temperature for 24 hours. The volatiles fractions were evaporated and the residue was dried under vacuum. Crude of 2-(5-(methylsulfonamido)-2-oxoindolin-1-yl)acetic acid (0.130 g, 0.446 mmol, 100% yield) was used for the next step without any further purification. MS/ESI+ 284.9 [MH]+.

Workup

  1. customThe volatiles fractions were evaporated
  2. customthe residue was dried under vacuum

Sources & evidence

ORD record
ord-dec2f36adbe342e0bed24401a619bde6
Source dataset
uspto-grants-2015_05
Patent number
US09024027B2

Reaction notes

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