Trifluoroacetic acid → HCID 86708897, compound

HRID 571355Notes

Reaction equation

HRID 571355 reaction equation
C(OC(=O)[NH:7][C@@H:8]1[CH2:17][C@H:11]2[CH2:12][N:13]([C:15]#[N:16])[CH2:14][C@@:10]2([C:18]([N:20]2[CH2:29][CH2:28][C:27]3[N:26]=[CH:25][C:24]([C:30]([F:33])([F:32])[F:31])=[CH:23][C:22]=3[CH2:21]2)=[O:19])[CH2:9]1)(C)(C)C.[C:35]([OH:41])([C:37]([F:40])([F:39])[F:38])=[O:36]>C(Cl)Cl>[F:38][C:37]([F:40])([F:39])[C:35]([OH:41])=[O:36].[NH2:7][C@@H:8]1[CH2:17][C@H:11]2[CH2:12][N:13]([C:15]([NH2:16])=[O:36])[CH2:14][C@@:10]2([C:18]([N:20]2[CH2:29][CH2:28][C:27]3[N:26]=[CH:25][C:24]([C:30]([F:31])([F:33])[F:32])=[CH:23][C:22]=3[CH2:21]2)=[O:19])[CH2:9]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 131732812HCID 131732812, compound

Product 1

HCID 86708897HCID 86708897, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of the product from Step A (0.19 g, 0.396 mmol) in TFA (1.5 mL) and DCM (1.5 mL) was stirred at rt for 1.5 h. Concentration by rotary evaporation was followed by dilution with DCM and additional evaporation to give the product as a TFA salt. LC/MS: C18H22F3N5O2: m/z 398.3 (M+H).

Workup

  1. concentrationConcentration
  2. customby rotary evaporation
  3. customwas followed by dilution with DCM and additional evaporation

Sources & evidence

ORD record
ord-90bd3bdc94cc46e6b8ac00cb34576264
Source dataset
uspto-grants-2015_05
Patent number
US09024017B2

Reaction notes

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